5-Methoxy tryptamine (5-MT), also known as mexamine, is a tryptamine derivative closelyrelated to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.[1] It is biosynthesized via the deacetylation of melatonin in the pineal gland.
5-MT acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7receptors. It has no affinity for the 5-HT3 receptor and it should also be noted that its affinity for the 5-HT1E receptor is very weak in comparison to the other 5-HT1 receptors. Its affinity for the 5-HT5A receptor is unknown

Application Area:
Phenylethylamine is an important pharmaceutical and dye intermediate, and is mainly used in medicine for the synthesis of benzylamine penicillin and hypoglycemic agents. The intermediate of the drug hypoglycemic is also used in other organic synthesis. Products such as glipizide can be produced using β-phenethylamine.