The reactions that produce, consume, and regenerate SAM are called the SAM cycle. In the first step of this cycle, the SAM-dependent methylases that use SAM as a substrate produce S-adenosyl homocysteine as a product.This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes ofmethionine synthases (i.e. cobalamin-dependent or cobalamin independent .
S-adenosyl-l-methionine is made of APT and Met, is one kind of biological active molecule, It can be used in the therapy of depression, arthritis, chronic hepatitis and cholestasia; moreover, it can be used in the preventation of liver cancer, or relieve.
The reactions that produce, consume, and regenerate SAM are called the SAM cycle. In the first step of this cycle, the SAM-dependent methylases that use SAM as a substrate produce S-adenosyl homocysteine as a product.This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes ofmethionine synthases (i.e. cobalamin-dependent or cobalamin independent . This methionine can then be converted back to SAM, completing the cycle.In the rate-limiting step of the SAM cycle, MTHFR (methylenetetrahydrofolate reductase) irreversibly reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.
Function:
1.SAMe is a good nutrition for the liver,can prevent alcohol, drugs and the liver-cell injury;
2.SAMe has remarkable preventive effects on chronic active hepatitis, and other factors caused liver injury,heart disease, cancer and so on.
3.SAMe has been found to be as effective as pharmaceutical treatments for arthritis and major depression as well.
