Vitamin K2 MK4 is essential for the carboxylation of glutamate residues in certain proteins, to give-carboxyglutamate. This modification allows the protein to bind calcium, an essential event in the blood clotting cascade. Carboxylation of glutamate is also important in other proteins involved in the mobilization or transport of calcium. Vitamin K2 MK4 is also a known of SXR.  Currently in Japan,  Vitamin K2 is being used to treat the  degenerative bone disease osteoporosis.

Function:
Vitamin K2 MK4 is a fat-soluble vitamin,it is needed to  manufacture prothrombin,  a substance essential  for the normal clotting of blood.
1.Vitamin K2 MK4 is being used to  cure haemorrhage  caused by VK2 deficiency;  promotes the formation  of thrombin, accelerates blood clotting, maintains proper clotting time; also used as quick coagulant in surgeries or first aids
2. Vitamin K2 MK4 is being used  to treat the degenerative  bone disease  osteoporosis.;  VK2 produces a  specific protein known  as osteocalcin which can bind calcium,  therefore to increase  the density of bones  and to prevent fracture.
3. Vitamin K2 MK4 can prevent the disease of hepatocellular carcinoma in women with viral cirrhosis.
4. Vitamin K2 MK4 has function of diuresis, promotes the detoxifcation of liver and lowering the blood pressure.

Application Area:
(1) Vitamin K2 MK4 can be used for treatment and prevention of osteoporosis, vitamin  K2 generate bone  protein, and then together with the calcium of bone formation, increase bone density and prevent fractures.
(2) Vitamin K2 MK4 can prevent progression to liver cirrhosis.
(3) Vitamin K2 MK4 can be used for the lack of treatment of  hemorrhagic  disease  of vitamin  K2, and  promote the formation of prothrombin, accelerated blood clotting, maintain normal clotting time.