N-Hydroxysuccinimide, commonly known as NHS, is a hydroxylated succinimide that is widely used in the activation of carboxylic acids to NHS-esters to promote coupling with nucleophiles. This approach is most commonly employed in activating the free acid forms of fluorophores for promoting conjugation of these fluorophores to amine residues of proteins. Use of NHS ester activation has also been described in the synthesis of N-acyl amino acids.

Application Area:
Used for the synthesis of amino acid protectant, semi-synthetic kanamycin and pharmaceutical intermediates.N-hydroxybutyldiimide and its derivatives are important raw materials for the synthesis of peptides, antibiotics, amino acids and proteins.N-hydroxybutyldiimide is used in the preparation of active esters, and the inhibition of the optically active effect of peptide coupling has a wide range of USES in medicine, and is also a basic chemical raw material.